depression
Articles tagged with “depression”
Amygdala Astrocytes Drive Anxiety, Not Just Support It
New research in Neuron shows amygdala astrocytes actively regulate anxiety and threat assessment — with direct implications for ketamine's mechanism of action.
What Is the Response Rate for Ketamine Therapy?
Approximately 50 to 70 percent of patients with treatment-resistant depression respond to a course of low-dose ketamine infusions.
Ketamine and Neuroinflammation: How Anti-Inflammatory Effects Support Mental Health
An evidence-based review of ketamine's anti-inflammatory mechanisms, including cytokine modulation, microglial regulation, and blood-brain barrier effects, and how these properties contribute to its antidepressant efficacy.
Ketamine and the Gut-Brain Axis: How the Microbiome Influences Treatment Response
An in-depth look at the emerging research connecting ketamine therapy to the gut-brain axis, including how gut microbiome composition may predict and modulate ketamine's antidepressant and analgesic effects.
How Fast Does Ketamine Work for Depression?
Low-dose ketamine can produce antidepressant effects within hours, with most patients noticing improvement in 1 to 4 hours after an IV infusion.
Microdosing Ketamine Protocols: Sub-Therapeutic Dose Approaches
A detailed exploration of ketamine microdosing protocols, including rationale, dosing ranges, clinical applications, safety considerations, and how microdosing compares to standard sub-anesthetic dosing for depression and chronic pain.
Ketamine for Depression: A Comprehensive Evidence-Based Guide
An in-depth clinical guide examining the evidence for low-dose ketamine in the treatment of major depressive disorder and treatment-resistant depression. Covers mechanisms of action, clinical trial data, response predictors, duration of effect, maintenance strategies, and cost-benefit analysis.
Ketamine for Depression
Frequently asked questions about using low-dose ketamine to treat depression, including how it works, response rates, speed of onset, and maintenance strategies.
Dose-Response Relationships in Low-Dose Ketamine Therapy
An in-depth examination of ketamine dose-response curves across indications including depression, chronic pain, and procedural analgesia. Covers threshold doses, ceiling effects, and how response varies with clinical context.
Low-Dose Ketamine for Postpartum Depression
A clinical review of low-dose ketamine as a treatment for postpartum depression, covering the neurobiological rationale, clinical evidence, safety considerations during lactation, and practical protocols for this vulnerable patient population.
Does Ketamine Affect Sleep? Low-Dose Ketamine and Sleep Architecture
Evidence-based review of how low-dose ketamine affects sleep quality, architecture, and insomnia in patients with depression and chronic pain.
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