Low-Dose Ketamine Protocols
Administration, routes, infusion and nasal-spray protocols, maintenance schedules, tapering, and discontinuation for low-dose ketamine therapy.
Clinical framing
Protocol articles are educational and should be adapted only by appropriately licensed clinicians for an individual patient.
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3 articles
Microdosing Ketamine Protocols: Sub-Therapeutic Dose Approaches
What does ketamine microdosing involve? Review of dose ranges, clinical applications, safety considerations, and how it differs from standard low-dose care.
Discontinuing Ketamine Therapy: Tapering, Timing, and Monitoring
Clinical guidance on when and how to discontinue ketamine therapy, covering tapering protocols, relapse monitoring strategies, transition planning, and evidence-based criteria for treatment cessation.
What Happens During a Ketamine Infusion?
A ketamine infusion involves a 40-minute IV drip in a clinical setting, with vital sign monitoring and a 1 to 2 hour observation period afterward.
Microdosing Ketamine Protocols: Sub-Therapeutic Dose Approaches
What does ketamine microdosing involve? Review of dose ranges, clinical applications, safety considerations, and how it differs from standard low-dose care.
Discontinuing Ketamine Therapy: Tapering, Timing, and Monitoring
Clinical guidance on when and how to discontinue ketamine therapy, covering tapering protocols, relapse monitoring strategies, transition planning, and evidence-based criteria for treatment cessation.
What Happens During a Ketamine Infusion?
A ketamine infusion involves a 40-minute IV drip in a clinical setting, with vital sign monitoring and a 1 to 2 hour observation period afterward.
Integration Therapy After Ketamine Treatment
What does integration therapy after a ketamine session involve? Review of neurobiological rationale, timing, therapeutic frameworks, and durability of outcomes.
Clinical Monitoring During Ketamine Administration: Assessment Protocols
Comprehensive guide to clinical monitoring and assessment protocols during ketamine administration, covering hemodynamic monitoring, dissociation scales, and safety benchmarks.
Treatment-Resistant Depression Algorithms: Where Ketamine Fits
Analysis of where ketamine fits within treatment-resistant depression algorithms, reviewing staging models, sequencing strategies, and evidence-based positioning in the TRD pathway.
Low-Dose Ketamine in Emergency Psychiatry: Acute Management Protocols
Review of low-dose ketamine in emergency psychiatry settings, covering acute suicidal ideation management, agitation protocols, ED implementation, and rapid assessment frameworks.
Ketamine-Assisted Psychotherapy: Integrating Pharmacology and Psychotherapy
Comprehensive review of ketamine-assisted psychotherapy (KAP), examining models of integration between pharmacological neuroplasticity and psychotherapeutic modalities for enhanced outcomes.
Ketamine Combination Therapy: Augmentation Strategies with Existing Treatments
Review of ketamine combination therapy and augmentation strategies, examining interactions with antidepressants, lithium, benzodiazepines, and psychotherapy for optimized outcomes.
Ketamine Maintenance Infusion Protocols: Frequency and Duration Optimization
How often are ketamine maintenance infusions given? Review of frequency, duration, tapering strategies, and long-term outcomes for sustained low-dose response.
Standard IV Ketamine Infusion Protocols for Treatment-Resistant Depression
How are IV ketamine infusions dosed for treatment-resistant depression? Review of 0.5 mg/kg standard, session structure, monitoring, and evidence base.
Spravato (Esketamine) Nasal Spray Protocol and Administration Guidelines
How is Spravato (esketamine) nasal spray dosed? Review of induction and maintenance schedules, REMS monitoring, and how it compares with racemic ketamine.