Low-Dose Ketamine Protocols
Administration, routes, infusion and nasal-spray protocols, maintenance schedules, tapering, and discontinuation for low-dose ketamine therapy.
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Protocol articles are educational and should be adapted only by appropriately licensed clinicians for an individual patient.
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3 articles
Microdosing Ketamine Protocols: Sub-Therapeutic Dose Approaches
What does ketamine microdosing involve? Review of dose ranges, clinical applications, safety considerations, and how it differs from standard low-dose care.
Discontinuing Ketamine Therapy: Tapering, Timing, and Monitoring
Clinical guidance on when and how to discontinue ketamine therapy, covering tapering protocols, relapse monitoring strategies, transition planning, and evidence-based criteria for treatment cessation.
What Happens During a Ketamine Infusion?
The standard ketamine infusion dose is 0.5 mg/kg over 40 minutes. Learn what to expect before, during, and after your appointment.
Microdosing Ketamine Protocols: Sub-Therapeutic Dose Approaches
What does ketamine microdosing involve? Review of dose ranges, clinical applications, safety considerations, and how it differs from standard low-dose care.
Discontinuing Ketamine Therapy: Tapering, Timing, and Monitoring
Clinical guidance on when and how to discontinue ketamine therapy, covering tapering protocols, relapse monitoring strategies, transition planning, and evidence-based criteria for treatment cessation.
What Happens During a Ketamine Infusion?
The standard ketamine infusion dose is 0.5 mg/kg over 40 minutes. Learn what to expect before, during, and after your appointment.
Integration Therapy After Ketamine Treatment
What does integration therapy after a ketamine session involve? Review of neurobiological rationale, timing, therapeutic frameworks, and durability of outcomes.
Clinical Monitoring During Ketamine Administration: Assessment Protocols
See how online medical assessment and in-person clinical monitoring work together during ketamine treatment, from pre-treatment screening to discharge criteria.
Treatment-Resistant Depression Algorithms: Where Ketamine Fits
Analysis of where ketamine fits within treatment-resistant depression algorithms, reviewing staging models, sequencing strategies, and evidence-based positioning in the TRD pathway.
Low-Dose Ketamine in Emergency Psychiatry: Acute Management Protocols
Review of low-dose ketamine in emergency psychiatry settings, covering acute suicidal ideation management, agitation protocols, ED implementation, and rapid assessment frameworks.
Ketamine-Assisted Psychotherapy: Integrating Pharmacology and Psychotherapy
Learn how ketamine-assisted psychotherapy combines ketamine, preparation, and integration therapy, what the evidence shows, and what to ask a KAP program.
Ketamine Combination Therapy: Augmentation Strategies with Existing Treatments
Learn what current evidence says about ketamine combination therapy with antidepressants, benzodiazepines, mood stabilizers, and psychotherapy.
Ketamine Maintenance Infusion Protocols: Frequency and Duration Optimization
Learn what research supports about ketamine maintenance infusion protocols, including induction, treatment frequency, tapering, duration, monitoring, and relapse planning.
Standard IV Ketamine Infusion Protocols for Treatment-Resistant Depression
Learn how IV ketamine infusion protocols for treatment-resistant depression are commonly structured, monitored, and evaluated, including the 0.5 mg/kg research regimen.
Spravato (Esketamine) Nasal Spray Protocol and Administration Guidelines
Learn Spravato administration requirements, including REMS-certified dosing, two-hour monitoring, treatment schedules, safety checks, and discharge planning.