Safety
Browse all safety articles and resources.
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3 articlesKetamine and Liver Function Tests: Monitoring LFTs During Therapy
A clinical guide to liver function test monitoring during low-dose ketamine therapy, including baseline assessment, frequency of testing, interpreting abnormal results, and managing hepatotoxicity risk.
Low-Dose Ketamine and Alcohol: Patient Safety Guide
A safety-focused guide on the risks and clinical considerations of alcohol use during ketamine therapy, covering pharmacological interactions, metabolism, timing guidelines, and patient counseling strategies.
Ketamine and Benzodiazepines: Clinical Interaction Guide
An evidence-based analysis of the interaction between ketamine and benzodiazepines, examining efficacy attenuation, timing considerations, clinical evidence, and management strategies for prescribers.
Ketamine and SSRIs: Drug Interaction Deep Dive
A clinician-focused analysis of pharmacological interactions between ketamine and selective serotonin reuptake inhibitors, covering serotonin syndrome risk, clinical evidence on concurrent use, and dosing adjustment considerations.
How Long Do Ketamine Side Effects Last?
Most ketamine side effects resolve within 1 to 2 hours after an infusion ends, with subtle residual effects fading within 4 to 6 hours.
Is Ketamine Therapy Addictive?
When administered in a supervised clinical setting at low doses, ketamine therapy carries a low risk of addiction, though the drug does have abuse potential.
Can You Drive After Ketamine Treatment?
You should not drive for at least 24 hours after a ketamine infusion due to temporary cognitive and perceptual effects.
Ketamine and Bladder Health: Urological Safety at Therapeutic Doses
A clinical review of ketamine-associated urological toxicity, examining the evidence at recreational versus therapeutic dose levels, pathophysiological mechanisms, risk factors, monitoring recommendations, and protective strategies for patients receiving low-dose ketamine treatment.
Ketamine and Blood Pressure: What Patients Should Know
A patient-oriented clinical guide to understanding ketamine's effects on blood pressure, including why blood pressure rises during treatment, what levels are expected, who is at increased risk, and how clinicians manage cardiovascular responses.
Ketamine in Pregnancy and Lactation: Safety Considerations and Data Gaps
Comprehensive review of ketamine safety in pregnancy and lactation, examining preclinical developmental toxicity, limited human data, breastfeeding transfer, and risk-benefit framework.
Abuse Potential of Therapeutic Ketamine: Risk Stratification and Monitoring
Assessment of abuse potential for therapeutic ketamine, examining risk stratification approaches, monitoring strategies, and safeguards for clinical prescribing programs.
Ketamine Side Effects: A Complete Clinical Guide
Comprehensive evidence-based review of ketamine side effects including dissociation, nausea, cardiovascular changes, and cognitive effects for clinicians.
Ketamine Tolerance and Long-Term Use: What Clinicians Need to Know
Clinical review of tolerance development during long-term ketamine therapy, including mechanisms, detection strategies, and evidence-based management approaches.
Managing Nausea and Vomiting During Ketamine Therapy
Clinical guide to preventing and treating ketamine-induced nausea and vomiting, covering antiemetic protocols, risk factors, and non-pharmacological strategies.
Cognitive Effects of Repeated Low-Dose Ketamine: Neuropsychological Assessment
Review of cognitive effects of repeated low-dose ketamine treatment, covering acute and chronic impacts on memory, executive function, and neuropsychological assessment strategies.
Ketamine-Associated Hepatotoxicity: Risk Factors and Liver Function Monitoring
Review of ketamine-associated hepatotoxicity including risk factors, proposed mechanisms, liver function monitoring protocols, and clinical management for repeated therapeutic dosing.
Cardiovascular Effects of Low-Dose Ketamine: Hemodynamic Monitoring Guidelines
Evidence-based hemodynamic monitoring guidelines for low-dose ketamine, covering sympathomimetic cardiovascular effects, blood pressure management, and cardiac risk stratification.
Long-Term Safety Considerations for Ketamine Therapy
An evidence-based review of safety concerns associated with repeated or prolonged low-dose ketamine use, including urological toxicity, neurocognitive effects, hepatic complications, and the potential for psychological and physiological dependence.
Contraindications and Screening Protocols for Ketamine Therapy
A thorough guide to absolute and relative contraindications for low-dose ketamine, along with recommended screening protocols encompassing medical history, psychiatric evaluation, laboratory assessment, and informed consent procedures.