depression studies
Articles tagged with “depression studies”
Low-Dose Ketamine Case Studies: Clinical Outcomes and Lessons
Review five low-dose ketamine composite case studies, including depression, PTSD, CRPS, bipolar depression, and suicidal ideation, with research-backed clinical lessons.
Ketamine and Neuroinflammation: How Anti-Inflammatory Effects Support Mental Health
Ketamine lowers inflammatory cytokines and calms microglia, effects that support its antidepressant action alongside biomarker and questionnaire monitoring.
Sex Differences in Ketamine Treatment Response: Hormonal and Genetic Factors
What research says about sex differences in ketamine treatment response, including hormones, genetics, dosing questions, and the limits of current clinical evidence.
Glutamate System Modulation by Low-Dose Ketamine
Glutamate system modulation by low-dose ketamine works through NMDA receptor blockade, an AMPA-driven glutamate surge, and BDNF-linked plasticity.
Anti-Inflammatory Properties of Low-Dose Ketamine: Cytokine Modulation
Low-dose ketamine lowers IL-6 and TNF-alpha via NF-kappaB inhibition. See how cytokine modulation shapes its antidepressant and pain effects.
Ketamine-Opioid System Interactions: Naltrexone Studies and Debate
How ketamine interacts with opioid receptors, what the naltrexone blockade study found, and what it means for patients on opioid medications.
Ketamine and the Default Mode Network: Neuroimaging Evidence
How does ketamine affect the brain's default mode network? A review of fMRI, MEG, and PET studies on DMN connectivity, depression, and treatment response.
Ketamine, Neuroplasticity, and Brain-Derived Neurotrophic Factor
How does low-dose ketamine drive neuroplasticity? A look at BDNF release, TrkB and mTOR activation, and the synapse rebuilding behind its rapid antidepressant effect.
Meta-Analyses of Low-Dose Ketamine for Treatment-Resistant Depression
Meta-analyses of low-dose ketamine for treatment-resistant depression show large 24-hour effects and better durability for racemic ketamine than esketamine.
Rapid-Onset Antidepressant Mechanisms of Low-Dose Ketamine
Low-dose ketamine's rapid-onset antidepressant mechanisms explain why relief begins in hours, not weeks, via NMDA blockade and BDNF-driven synaptic growth.
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