dosing
Articles tagged with “dosing”
When to Switch or Stay: NMDA Therapy Discontinuation Rates
New analysis reveals why patients stop NMDA receptor antagonist therapy—and what discontinuation data means for low-dose ketamine monitoring and dosing decisions.
What Dropout Rates Reveal About NMDA Therapy Tolerability
New psychiatric guidance examines why patients stop NMDA antagonist therapy and what side effect data means for low-dose ketamine treatment decisions.
When Ketamine Side Effects Signal Time to Adjust Dose
New clinical analysis examines why patients stop NMDA antagonist therapy—and how smarter dose management may improve remission outcomes in TRD.
Faster TRD Remission Hinges on Measurement and Dose Timing
New analysis in Psychiatric Times shows that symptom tracking and rapid dose adjustment drive faster remission in TRD—here's what it means for ketamine care.
What Side Effect Data Tells Us About Ketamine Dosing
New analysis of NMDA receptor antagonist side effects in treatment-resistant depression underscores why dose optimization and early monitoring matter.
NMDA Antagonist Side Effects: What the Data Says
New clinical analysis examines why patients stop ketamine and esketamine treatment—and what smarter monitoring can do to keep them on track.
Ketamine Side Effects & When to Switch: New Clinical Guidance
New clinical guidance urges tracking PHQ-9 scores, monitoring side effects closely, and switching NMDA treatments sooner to reach remission faster.
Microdosing Ketamine Protocols: Sub-Therapeutic Dose Approaches
A detailed exploration of ketamine microdosing protocols, including rationale, dosing ranges, clinical applications, safety considerations, and how microdosing compares to standard sub-anesthetic dosing for depression and chronic pain.
Low-Dose Ketamine Case Studies: Clinical Outcomes and Lessons
Five anonymized clinical case studies illustrating treatment outcomes with low-dose ketamine across treatment-resistant depression, PTSD, chronic pain, and bipolar depression, with detailed dosing, timelines, and clinical lessons.
Tracking Treatment Response to Ketamine: PHQ-9, MADRS, and Clinical Scales
A clinician's guide to systematic outcome measurement in ketamine therapy, covering validated rating scales, assessment frequency, response and remission thresholds, and data-driven decision-making for dosing adjustments.
Dosing and Administration
Common questions about ketamine dosing, routes of administration, weight-based calculations, dose adjustments, and the differences between clinic and at-home treatment.
What Is Ketamine's Half-Life?
Ketamine has a plasma half-life of approximately 2 to 3 hours, though its antidepressant effects persist far longer due to downstream neuroplastic changes.
How Many Ketamine Treatments Are Needed?
A typical initial course of ketamine therapy consists of 6 IV infusions over 2 to 3 weeks, followed by maintenance treatments as needed.
What Is the Standard Ketamine Dose for Depression?
The standard ketamine dose for depression is 0.5 mg/kg administered intravenously over 40 minutes.
Ketamine Tolerance: Understanding Dose Adjustments Over Time
A clinical review of tolerance development during repeated ketamine treatment, covering pharmacological mechanisms of tolerance, clinical indicators, evidence-based dose adjustment strategies, and the distinction between therapeutic tolerance and treatment failure.
Pediatric Low-Dose Ketamine: Dosing Considerations and Safety
Review of pediatric low-dose ketamine dosing considerations, covering developmental pharmacokinetics, age-specific safety data, and clinical applications in children and adolescents.
Esketamine vs Racemic Ketamine Dosing: Comparative Pharmacology
Comparative pharmacology of esketamine versus racemic ketamine dosing, examining enantiomer-specific receptor binding, clinical potency differences, and dosing equivalencies.
Optimizing Oral Ketamine Bioavailability: Pharmacokinetic Strategies
Pharmacokinetic strategies for optimizing oral ketamine bioavailability, including sublingual administration, formulation approaches, metabolic inhibition, and clinical considerations.
Weight-Based Dosing Guidelines for Low-Dose Ketamine
Practical guidance on weight-based dosing calculations for low-dose ketamine across clinical indications. Addresses ideal versus actual body weight considerations, dosing ranges by route and indication, and special population adjustments.
Standard IV Ketamine Infusion Protocols for Treatment-Resistant Depression
A comprehensive overview of intravenous ketamine infusion protocols used in clinical settings for treatment-resistant depression, including dosing parameters, session structure, monitoring requirements, and evidence-based best practices.
Geriatric Considerations in Low-Dose Ketamine Therapy
Clinical guidance on low-dose ketamine use in elderly patients, addressing age-related pharmacokinetic changes, cardiovascular risk stratification, cognitive monitoring, and dose modifications.
Pharmacokinetics of Ketamine: Absorption, Distribution, Metabolism, and Elimination
A comprehensive overview of ketamine pharmacokinetics across all clinically relevant routes of administration. Covers bioavailability, volume of distribution, hepatic metabolism via CYP enzymes, half-life considerations, and the role of active metabolites.
Renal and Hepatic Dose Adjustments for Low-Dose Ketamine
Pharmacokinetic rationale and clinical guidelines for ketamine dose adjustments in patients with renal impairment or hepatic dysfunction, including monitoring strategies and contraindication thresholds.
Defining Sub-Anesthetic Ketamine: Dose Ranges and Therapeutic Windows
Comprehensive guide to sub-anesthetic ketamine dose ranges and therapeutic windows, covering pharmacological thresholds, receptor occupancy, and clinical dose-response relationships.
Dose-Response Relationships in Low-Dose Ketamine Therapy
An in-depth examination of ketamine dose-response curves across indications including depression, chronic pain, and procedural analgesia. Covers threshold doses, ceiling effects, and how response varies with clinical context.
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