glutamate
Articles tagged with “glutamate”
Ketamine and Benzodiazepines: Clinical Interaction Guide
An evidence-based analysis of the interaction between ketamine and benzodiazepines, examining efficacy attenuation, timing considerations, clinical evidence, and management strategies for prescribers.
Rapid-Onset Antidepressant Mechanisms of Low-Dose Ketamine
An in-depth examination of why and how low-dose ketamine produces antidepressant effects within hours rather than weeks. This article reviews the glutamatergic hypothesis, the role of spontaneous NMDA receptor activity, and emerging theories that distinguish ketamine from conventional antidepressants.
Glutamate System Modulation by Low-Dose Ketamine
A comprehensive analysis of how low-dose ketamine modulates the glutamate system, including NMDA receptor antagonism, AMPA receptor potentiation, and the glutamate surge hypothesis. Reviews the excitatory-inhibitory balance framework and its therapeutic implications.
The Complete Guide to Low-Dose Ketamine Therapy
A comprehensive, evidence-based guide covering what low-dose ketamine is, how it works, all routes of administration, what patients can expect during treatment, efficacy data across conditions, safety considerations, and how to find qualified providers.
Low-Dose Ketamine for Treatment-Resistant Depression
An evidence-based overview of low-dose ketamine as a rapidly acting antidepressant for patients with treatment-resistant depression, including mechanisms of action, clinical protocols, and outcome data.
Low-Dose Ketamine for Social Anxiety Disorder: Preliminary Evidence
Examining preliminary evidence for low-dose ketamine in social anxiety disorder, including glutamatergic mechanisms, neuroimaging findings, and early-phase clinical data.
Ketamine for OCD: Glutamatergic Modulation of Obsessive-Compulsive Circuits
Review of ketamine in OCD treatment, examining glutamatergic modulation of cortico-striato-thalamo-cortical circuits, clinical trial evidence, and rapid anti-obsessional effects.
Low-Dose Ketamine for Anxiety Disorders
A clinical overview of subanesthetic ketamine's therapeutic potential in generalized anxiety disorder, social anxiety disorder, and obsessive-compulsive disorder, including mechanistic pathways, current evidence, and considerations for clinical practice.
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