ketamine
Articles tagged with “ketamine”
What a Year of Experimental Depression Treatment Reveals
A Guardian journalist spent a year testing ketamine, TMS, and gut therapy for depression. Here's what their experience reveals about low-dose ketamine.
What Side Effect Data Tells Us About Ketamine Dosing
New analysis of NMDA receptor antagonist side effects in treatment-resistant depression underscores why dose optimization and early monitoring matter.
NMDA Antagonist Side Effects: What the Data Says
New clinical analysis examines why patients stop ketamine and esketamine treatment—and what smarter monitoring can do to keep them on track.
How Clinicians Choose TRD Treatments in 2026
New clinical guidance on treatment-resistant depression highlights how patient preference, speed of response, and functional outcomes shape ketamine treatment decisions.
Ketamine vs Traditional Antidepressants: Mechanism, Efficacy, and Clinical Role
Ketamine vs SSRIs, SNRIs, and TCAs: how mechanisms, onset, efficacy in treatment-resistant depression, side effects, and access compare in current evidence.
Ketamine vs TMS (Transcranial Magnetic Stimulation): Two Approaches to Treatment-Resistant Depression
Ketamine vs TMS for treatment-resistant depression: mechanisms, success rates, protocols, side effects, FDA status, and cost compared side by side.
Ketamine and Blood Pressure: What Patients Should Know
A patient-oriented clinical guide to understanding ketamine's effects on blood pressure, including why blood pressure rises during treatment, what levels are expected, who is at increased risk, and how clinicians manage cardiovascular responses.
Low-Dose Ketamine for Chronic Migraine
A clinical review of subanesthetic ketamine for chronic and refractory migraine, including NMDA receptor mechanisms in migraine pathophysiology, evidence from clinical studies, infusion protocols, and safety considerations.
Telehealth Ketamine Therapy: Protocols and Best Practices
How does telehealth ketamine therapy work? Review of remote prescribing rules, sublingual protocols, patient selection, and monitoring in virtual care models.
Integration Therapy After Ketamine Treatment
What does integration therapy after a ketamine session involve? Review of neurobiological rationale, timing, therapeutic frameworks, and durability of outcomes.
Ketamine and Neuroinflammation: How Anti-Inflammatory Effects Support Mental Health
An evidence-based review of ketamine's anti-inflammatory mechanisms, including cytokine modulation, microglial regulation, and blood-brain barrier effects, and how these properties contribute to its antidepressant efficacy.
Ketamine and Bladder Health: Urological Safety at Therapeutic Doses
Does low-dose ketamine cause bladder problems? Review of urological risk at therapeutic vs recreational doses, mechanisms, and monitoring recommendations.
Low-Dose Ketamine for Postpartum Depression
A clinical review of low-dose ketamine as a treatment for postpartum depression, covering the neurobiological rationale, clinical evidence, safety considerations during lactation, and practical protocols for this vulnerable patient population.
Ketamine Tolerance: Understanding Dose Adjustments Over Time
Do patients build tolerance to ketamine? A clinical review of tolerance mechanisms, clinical signs, and evidence on adjusting dose over repeated treatment.
Abuse Potential of Therapeutic Ketamine: Risk Stratification and Monitoring
Assessment of abuse potential for therapeutic ketamine, examining risk stratification approaches, monitoring strategies, and safeguards for clinical prescribing programs.
Low-Dose Ketamine in Emergency Psychiatry: Acute Management Protocols
Review of low-dose ketamine in emergency psychiatry settings, covering acute suicidal ideation management, agitation protocols, ED implementation, and rapid assessment frameworks.
Glutamate System Modulation by Low-Dose Ketamine
A comprehensive analysis of how low-dose ketamine modulates the glutamate system, including NMDA receptor antagonism, AMPA receptor potentiation, and the glutamate surge hypothesis. Reviews the excitatory-inhibitory balance framework and its therapeutic implications.
Ketamine Effects on Sleep Architecture: Slow-Wave Sleep and REM Changes
How does low-dose ketamine affect sleep? Review of slow-wave sleep enhancement, REM modulation, and links between sleep architecture and antidepressant action.
Sub-Anesthetic Ketamine for Fibromyalgia: Analgesic Mechanisms and Outcomes
Evidence review of sub-anesthetic ketamine for fibromyalgia pain, examining central sensitization reversal, NMDA receptor mechanisms, and clinical outcomes from infusion studies.
Ketamine Side Effects: A Complete Clinical Guide
Comprehensive evidence-based review of ketamine side effects including dissociation, nausea, cardiovascular changes, and cognitive effects for clinicians.
Ketamine Tolerance and Long-Term Use: What Clinicians Need to Know
Clinical review of tolerance development during long-term ketamine therapy, including mechanisms, detection strategies, and evidence-based management approaches.
Cognitive Effects of Repeated Low-Dose Ketamine: Neuropsychological Assessment
Does repeated low-dose ketamine affect cognition? Review of memory, attention, and executive function testing across short- and longer-term treatment courses.
Does Ketamine Affect Sleep? Low-Dose Ketamine and Sleep Architecture
Does ketamine affect sleep? Review of how low-dose ketamine influences sleep quality, insomnia, and sleep architecture in depression and chronic pain patients.
Anti-Inflammatory Properties of Low-Dose Ketamine: Cytokine Modulation
Review of the anti-inflammatory properties of low-dose ketamine, examining cytokine modulation, NF-kappaB signaling, microglial inhibition, and implications for depression and pain.
BDNF Signaling and Ketamine's Antidepressant Action
A detailed examination of how ketamine activates brain-derived neurotrophic factor signaling, TrkB receptor pathways, and the mTOR cascade to produce rapid antidepressant effects. Covers molecular mechanisms, clinical evidence, and implications for personalized treatment.
Ketamine-Associated Hepatotoxicity: Risk Factors and Liver Function Monitoring
Review of ketamine-associated hepatotoxicity including risk factors, proposed mechanisms, liver function monitoring protocols, and clinical management for repeated therapeutic dosing.
Low-Dose Ketamine for Social Anxiety Disorder: Preliminary Evidence
Examining preliminary evidence for low-dose ketamine in social anxiety disorder, including glutamatergic mechanisms, neuroimaging findings, and early-phase clinical data.
Ketamine for OCD: Glutamatergic Modulation of Obsessive-Compulsive Circuits
Review of ketamine in OCD treatment, examining glutamatergic modulation of cortico-striato-thalamo-cortical circuits, clinical trial evidence, and rapid anti-obsessional effects.
Neuroplasticity Mechanisms in Ketamine Therapy
An in-depth exploration of how low-dose ketamine promotes neural rewiring, synaptogenesis, and dendritic spine formation. This article examines the molecular and cellular pathways through which ketamine restores synaptic connectivity in mood and pain disorders.
Ketamine-Opioid System Interactions: Naltrexone Studies and Debate
Analysis of ketamine-opioid system interactions, examining the naltrexone blockade controversy, mu-receptor involvement in antidepressant effects, and implications for clinical practice.
Cardiovascular Effects of Low-Dose Ketamine: Hemodynamic Monitoring Guidelines
Evidence-based hemodynamic monitoring guidelines for low-dose ketamine, covering sympathomimetic cardiovascular effects, blood pressure management, and cardiac risk stratification.
Low-Dose Ketamine for Bipolar Depression: Efficacy and Safety Data
Comprehensive review of low-dose ketamine for bipolar depression, examining clinical trial efficacy, safety profiles, and rapid-acting antidepressant mechanisms in bipolar disorder.
Ketamine and the Default Mode Network: Neuroimaging Evidence
What does ketamine do to the default mode network? A review of fMRI connectivity studies, DMN changes in depression, and what the imaging evidence shows.
Meta-Analyses of Low-Dose Ketamine for Treatment-Resistant Depression
A comprehensive review of major meta-analyses examining the efficacy and safety of low-dose ketamine in treatment-resistant depression. This overview synthesizes findings across multiple systematic reviews to characterize effect sizes, response rates, and durability of antidepressant outcomes.
Ketamine, Neuroplasticity, and Brain-Derived Neurotrophic Factor
How does low-dose ketamine drive neuroplasticity? Review of BDNF, mTOR pathway activation, synaptogenesis, and links to rapid antidepressant effects.
Low-Dose Ketamine for Acute Suicidal Ideation: Clinical Evidence
A review of the clinical trial evidence examining low-dose ketamine as an intervention for acute suicidal ideation. This article evaluates randomized controlled trials, naturalistic studies, and emergency department protocols demonstrating ketamine's rapid anti-suicidal effects.
Rapid-Onset Antidepressant Mechanisms of Low-Dose Ketamine
An in-depth examination of why and how low-dose ketamine produces antidepressant effects within hours rather than weeks. This article reviews the glutamatergic hypothesis, the role of spontaneous NMDA receptor activity, and emerging theories that distinguish ketamine from conventional antidepressants.
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