ketamine
Articles tagged with “ketamine”
Ketamine Tolerance and Long-Term Use: What Clinicians Need to Know
Clinical review of tolerance development during long-term ketamine therapy, including mechanisms, detection strategies, and evidence-based management approaches.
Ketamine and Bladder Health: Urological Safety at Therapeutic Doses
A clinical review of ketamine-associated urological toxicity, examining the evidence at recreational versus therapeutic dose levels, pathophysiological mechanisms, risk factors, monitoring recommendations, and protective strategies for patients receiving low-dose ketamine treatment.
Ketamine and Blood Pressure: What Patients Should Know
A patient-oriented clinical guide to understanding ketamine's effects on blood pressure, including why blood pressure rises during treatment, what levels are expected, who is at increased risk, and how clinicians manage cardiovascular responses.
Ketamine-Associated Hepatotoxicity: Risk Factors and Liver Function Monitoring
Review of ketamine-associated hepatotoxicity including risk factors, proposed mechanisms, liver function monitoring protocols, and clinical management for repeated therapeutic dosing.
Ketamine Side Effects: A Complete Clinical Guide
Comprehensive evidence-based review of ketamine side effects including dissociation, nausea, cardiovascular changes, and cognitive effects for clinicians.
Cardiovascular Effects of Low-Dose Ketamine: Hemodynamic Monitoring Guidelines
Evidence-based hemodynamic monitoring guidelines for low-dose ketamine, covering sympathomimetic cardiovascular effects, blood pressure management, and cardiac risk stratification.
Cognitive Effects of Repeated Low-Dose Ketamine: Neuropsychological Assessment
Review of cognitive effects of repeated low-dose ketamine treatment, covering acute and chronic impacts on memory, executive function, and neuropsychological assessment strategies.
Abuse Potential of Therapeutic Ketamine: Risk Stratification and Monitoring
Assessment of abuse potential for therapeutic ketamine, examining risk stratification approaches, monitoring strategies, and safeguards for clinical prescribing programs.
Low-Dose Ketamine for Acute Suicidal Ideation: Clinical Evidence
A review of the clinical trial evidence examining low-dose ketamine as an intervention for acute suicidal ideation. This article evaluates randomized controlled trials, naturalistic studies, and emergency department protocols demonstrating ketamine's rapid anti-suicidal effects.
Ketamine Effects on Sleep Architecture: Slow-Wave Sleep and REM Changes
Examining ketamine's effects on sleep architecture including slow-wave sleep enhancement, REM sleep modulation, and implications for the sleep-depression-neuroplasticity axis.
Rapid-Onset Antidepressant Mechanisms of Low-Dose Ketamine
An in-depth examination of why and how low-dose ketamine produces antidepressant effects within hours rather than weeks. This article reviews the glutamatergic hypothesis, the role of spontaneous NMDA receptor activity, and emerging theories that distinguish ketamine from conventional antidepressants.
Ketamine-Opioid System Interactions: Naltrexone Studies and Debate
Analysis of ketamine-opioid system interactions, examining the naltrexone blockade controversy, mu-receptor involvement in antidepressant effects, and implications for clinical practice.
Neuroplasticity Mechanisms in Ketamine Therapy
An in-depth exploration of how low-dose ketamine promotes neural rewiring, synaptogenesis, and dendritic spine formation. This article examines the molecular and cellular pathways through which ketamine restores synaptic connectivity in mood and pain disorders.
Ketamine, Neuroplasticity, and Brain-Derived Neurotrophic Factor
An exploration of the molecular and cellular mechanisms by which low-dose ketamine promotes neuroplasticity. This article reviews the role of BDNF signaling, mTOR pathway activation, and synaptogenesis in mediating ketamine's antidepressant effects.
Meta-Analyses of Low-Dose Ketamine for Treatment-Resistant Depression
A comprehensive review of major meta-analyses examining the efficacy and safety of low-dose ketamine in treatment-resistant depression. This overview synthesizes findings across multiple systematic reviews to characterize effect sizes, response rates, and durability of antidepressant outcomes.
Ketamine and Neuroinflammation: How Anti-Inflammatory Effects Support Mental Health
An evidence-based review of ketamine's anti-inflammatory mechanisms, including cytokine modulation, microglial regulation, and blood-brain barrier effects, and how these properties contribute to its antidepressant efficacy.
Glutamate System Modulation by Low-Dose Ketamine
A comprehensive analysis of how low-dose ketamine modulates the glutamate system, including NMDA receptor antagonism, AMPA receptor potentiation, and the glutamate surge hypothesis. Reviews the excitatory-inhibitory balance framework and its therapeutic implications.
Ketamine and the Default Mode Network: Neuroimaging Evidence
Review of neuroimaging evidence on ketamine's effects on the default mode network (DMN), examining fMRI connectivity changes, depression biomarkers, and implications for treatment.
BDNF Signaling and Ketamine's Antidepressant Action
A detailed examination of how ketamine activates brain-derived neurotrophic factor signaling, TrkB receptor pathways, and the mTOR cascade to produce rapid antidepressant effects. Covers molecular mechanisms, clinical evidence, and implications for personalized treatment.
Anti-Inflammatory Properties of Low-Dose Ketamine: Cytokine Modulation
Review of the anti-inflammatory properties of low-dose ketamine, examining cytokine modulation, NF-kappaB signaling, microglial inhibition, and implications for depression and pain.
Telehealth Ketamine Therapy: Protocols and Best Practices
A comprehensive guide to telehealth-delivered ketamine therapy, covering regulatory frameworks, clinical protocols for remote prescribing and monitoring, patient selection, and quality standards for virtual ketamine treatment programs.
Integration Therapy After Ketamine Treatment
An evidence-based guide to psychological integration following ketamine treatment sessions, covering the neurobiological rationale for integration, therapeutic frameworks, timing considerations, and practical strategies for maximizing treatment durability.
Ketamine Tolerance: Understanding Dose Adjustments Over Time
A clinical review of tolerance development during repeated ketamine treatment, covering pharmacological mechanisms of tolerance, clinical indicators, evidence-based dose adjustment strategies, and the distinction between therapeutic tolerance and treatment failure.
Low-Dose Ketamine for Social Anxiety Disorder: Preliminary Evidence
Examining preliminary evidence for low-dose ketamine in social anxiety disorder, including glutamatergic mechanisms, neuroimaging findings, and early-phase clinical data.
Ketamine for OCD: Glutamatergic Modulation of Obsessive-Compulsive Circuits
Review of ketamine in OCD treatment, examining glutamatergic modulation of cortico-striato-thalamo-cortical circuits, clinical trial evidence, and rapid anti-obsessional effects.
Low-Dose Ketamine for Postpartum Depression
A clinical review of low-dose ketamine as a treatment for postpartum depression, covering the neurobiological rationale, clinical evidence, safety considerations during lactation, and practical protocols for this vulnerable patient population.
Low-Dose Ketamine for Chronic Migraine
A clinical review of subanesthetic ketamine for chronic and refractory migraine, including NMDA receptor mechanisms in migraine pathophysiology, evidence from clinical studies, infusion protocols, and safety considerations.
Does Ketamine Affect Sleep? Low-Dose Ketamine and Sleep Architecture
Evidence-based review of how low-dose ketamine affects sleep quality, architecture, and insomnia in patients with depression and chronic pain.
Sub-Anesthetic Ketamine for Fibromyalgia: Analgesic Mechanisms and Outcomes
Evidence review of sub-anesthetic ketamine for fibromyalgia pain, examining central sensitization reversal, NMDA receptor mechanisms, and clinical outcomes from infusion studies.
Low-Dose Ketamine for Bipolar Depression: Efficacy and Safety Data
Comprehensive review of low-dose ketamine for bipolar depression, examining clinical trial efficacy, safety profiles, and rapid-acting antidepressant mechanisms in bipolar disorder.
Ketamine vs Traditional Antidepressants: Mechanism, Efficacy, and Clinical Role
Comprehensive comparison of ketamine therapy versus traditional antidepressants (SSRIs, SNRIs, TCAs) for depression, covering onset of action, mechanisms, efficacy in treatment-resistant depression, side effects, cost, and access.
Ketamine vs TMS (Transcranial Magnetic Stimulation): Two Approaches to Treatment-Resistant Depression
Evidence-based comparison of ketamine therapy and transcranial magnetic stimulation (TMS) for treatment-resistant depression, examining mechanisms, treatment protocols, efficacy, side effects, FDA approval status, cost, and convenience.
Low-Dose Ketamine in Emergency Psychiatry: Acute Management Protocols
Review of low-dose ketamine in emergency psychiatry settings, covering acute suicidal ideation management, agitation protocols, ED implementation, and rapid assessment frameworks.
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