pharmacokinetics
Articles tagged with “pharmacokinetics”
Ketamine Bioavailability by Route: A Patient Comparison
How sublingual, oral, intranasal, IM, and IV ketamine compare on bioavailability and why route shapes both dose and effect. A patient-friendly low-dose framing.
Ketamine Dosing and Administration: A Complete Clinical Guide
Reference guide to ketamine dosage across IV, oral, sublingual troche, and intranasal routes — weight-based dosing, titration, and route-specific protocols.
Sublingual vs Oral (Swallowed) Ketamine: Absorption and Efficacy Differences
Detailed comparison of sublingual and oral (swallowed) ketamine administration routes, covering bioavailability differences, onset of action, first-pass metabolism, dosing strategies, taste considerations, and clinical outcomes.
What Is Ketamine's Half-Life?
How long does ketamine stay active? A look at the 2-3 hour plasma half-life, norketamine metabolism, and why antidepressant effects outlast the drug itself.
How Long Do Ketamine's Antidepressant Effects Last?
The antidepressant effects of a single ketamine infusion typically last 3 to 14 days, with repeated treatments extending the duration of benefit.
How Fast Does Ketamine Work for Depression?
Low-dose ketamine can produce antidepressant effects within hours, with most patients noticing improvement in 1 to 4 hours after an IV infusion.
Optimizing Oral Ketamine Bioavailability: Pharmacokinetic Strategies
How is oral ketamine bioavailability improved? Review of sublingual delivery, formulation choices, metabolic inhibition, and low-dose implications.
Pharmacokinetics of Ketamine: Absorption, Distribution, Metabolism, and Elimination
A comprehensive overview of ketamine pharmacokinetics across all clinically relevant routes of administration. Covers bioavailability, volume of distribution, hepatic metabolism via CYP enzymes, half-life considerations, and the role of active metabolites.
Renal and Hepatic Dose Adjustments for Low-Dose Ketamine
How is low-dose ketamine adjusted for kidney or liver impairment? Review of pharmacokinetic rationale, dose modification, and monitoring in at-risk patients.
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