Ketamine Pharmacokinetics
Half-life, absorption, metabolism, bioavailability by route, onset, and duration of low-dose ketamine, how fast it works and how long effects last.
Why PK matters
Understanding absorption and elimination helps explain dosing intervals, route differences, and how quickly antidepressant effects appear and fade.
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Ketamine Bioavailability by Route: A Patient Comparison
How sublingual, oral, intranasal, IM, and IV ketamine compare on bioavailability and why route shapes both dose and effect. A patient-friendly low-dose framing.
How Long Do Ketamine's Antidepressant Effects Last?
The antidepressant effects of a single ketamine infusion typically last 3 to 14 days, with repeated treatments extending the duration of benefit.
How Fast Does Ketamine Work for Depression?
Low-dose ketamine eases depression symptoms within 1-4 hours, with peak effects at 24-72 hours, compared to 4-6 weeks for SSRIs. See the full timeline.
What Is Ketamine's Half-Life?
How long does ketamine stay active? A look at the 2-3 hour plasma half-life, norketamine metabolism, and why antidepressant effects outlast the drug itself.
Optimizing Oral Ketamine Bioavailability: Pharmacokinetic Strategies
How is oral ketamine bioavailability improved? Review of sublingual delivery, formulation choices, metabolic inhibition, and low-dose implications.
Pharmacokinetics of Ketamine: Absorption, Distribution, Metabolism, and Elimination
Learn how ketamine is absorbed, distributed, metabolized, and eliminated across IV, intranasal, oral, sublingual, IM, and subcutaneous routes.