Dosing Articles
Latest articles, insights, and updates from the blog.
Tracking Treatment Response to Ketamine: PHQ-9, MADRS, and Clinical Scales
A clinician's guide to systematic outcome measurement in ketamine therapy, covering validated rating scales, assessment frequency, response and remission thresholds, and data-driven decision-making for dosing adjustments.
What Is Ketamine's Half-Life?
Ketamine has a plasma half-life of approximately 2 to 3 hours, though its antidepressant effects persist far longer due to downstream neuroplastic changes.
How Many Ketamine Treatments Are Needed?
A typical initial course of ketamine therapy consists of 6 IV infusions over 2 to 3 weeks, followed by maintenance treatments as needed.
What Is the Standard Ketamine Dose for Depression?
The standard ketamine dose for depression is 0.5 mg/kg administered intravenously over 40 minutes.
Ketamine Tolerance: Understanding Dose Adjustments Over Time
A clinical review of tolerance development during repeated ketamine treatment, covering pharmacological mechanisms of tolerance, clinical indicators, evidence-based dose adjustment strategies, and the distinction between therapeutic tolerance and treatment failure.
Pediatric Low-Dose Ketamine: Dosing Considerations and Safety
Review of pediatric low-dose ketamine dosing considerations, covering developmental pharmacokinetics, age-specific safety data, and clinical applications in children and adolescents.
Esketamine vs Racemic Ketamine Dosing: Comparative Pharmacology
Comparative pharmacology of esketamine versus racemic ketamine dosing, examining enantiomer-specific receptor binding, clinical potency differences, and dosing equivalencies.
Optimizing Oral Ketamine Bioavailability: Pharmacokinetic Strategies
Pharmacokinetic strategies for optimizing oral ketamine bioavailability, including sublingual administration, formulation approaches, metabolic inhibition, and clinical considerations.
Weight-Based Dosing Guidelines for Low-Dose Ketamine
Practical guidance on weight-based dosing calculations for low-dose ketamine across clinical indications. Addresses ideal versus actual body weight considerations, dosing ranges by route and indication, and special population adjustments.
Pharmacokinetics of Ketamine: Absorption, Distribution, Metabolism, and Elimination
A comprehensive overview of ketamine pharmacokinetics across all clinically relevant routes of administration. Covers bioavailability, volume of distribution, hepatic metabolism via CYP enzymes, half-life considerations, and the role of active metabolites.
Renal and Hepatic Dose Adjustments for Low-Dose Ketamine
Pharmacokinetic rationale and clinical guidelines for ketamine dose adjustments in patients with renal impairment or hepatic dysfunction, including monitoring strategies and contraindication thresholds.
Defining Sub-Anesthetic Ketamine: Dose Ranges and Therapeutic Windows
Comprehensive guide to sub-anesthetic ketamine dose ranges and therapeutic windows, covering pharmacological thresholds, receptor occupancy, and clinical dose-response relationships.
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