Research Articles
Latest articles, insights, and updates from the blog.
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Ketamine and the Gut-Brain Axis: How the Microbiome Influences Treatment Response
An in-depth look at the emerging research connecting ketamine therapy to the gut-brain axis, including how gut microbiome composition may predict and modulate ketamine's antidepressant and analgesic effects.
Ketamine and Immune Function: Immunomodulatory Effects of Low-Dose Ketamine
A research-focused review of ketamine's effects on the immune system, including its impact on innate and adaptive immunity, inflammatory cytokines, immune cell function, and implications for patients with autoimmune conditions and chronic inflammation.
Low-Dose Ketamine Case Studies: Clinical Outcomes and Lessons
What do published low-dose ketamine case studies show? Review of clinical outcomes, dosing patterns, and lessons across depression, pain, and anxiety cases.
How to Start a Ketamine Therapy Practice: A Clinician's Guide
A comprehensive guide for clinicians on launching a ketamine therapy practice, covering DEA licensing, state regulations, clinical protocols, compounding pharmacy partnerships, liability considerations, and insurance frameworks.
The Complete Guide to Low-Dose Ketamine Therapy
A comprehensive, evidence-based guide covering what low-dose ketamine is, how it works, all routes of administration, what patients can expect during treatment, efficacy data across conditions, safety considerations, and how to find qualified providers.
What Is the Response Rate for Ketamine Therapy?
Approximately 50 to 70 percent of patients with treatment-resistant depression respond to a course of low-dose ketamine infusions.
Biomarkers for Predicting Ketamine Treatment Response
A review of emerging biological markers that may predict which patients will respond to ketamine therapy, including inflammatory markers, neuroimaging signatures, genetic polymorphisms, and electrophysiological features.
Ketamine and Neuroinflammation: How Anti-Inflammatory Effects Support Mental Health
An evidence-based review of ketamine's anti-inflammatory mechanisms, including cytokine modulation, microglial regulation, and blood-brain barrier effects, and how these properties contribute to its antidepressant efficacy.
Sex Differences in Ketamine Treatment Response: Hormonal and Genetic Factors
Examining sex differences in ketamine treatment response, covering estrogen-NMDA interactions, progesterone modulation, genetic factors, and implications for personalized dosing.
Glutamate System Modulation by Low-Dose Ketamine
A comprehensive analysis of how low-dose ketamine modulates the glutamate system, including NMDA receptor antagonism, AMPA receptor potentiation, and the glutamate surge hypothesis. Reviews the excitatory-inhibitory balance framework and its therapeutic implications.
Ketamine Effects on Sleep Architecture: Slow-Wave Sleep and REM Changes
How does low-dose ketamine affect sleep? Review of slow-wave sleep enhancement, REM modulation, and links between sleep architecture and antidepressant action.
Telehealth Ketamine Marketing Compliance: Regulatory and Ethical Guidelines
What rules govern telehealth ketamine advertising? Review of FDA, FTC, and state guidance on marketing low-dose ketamine therapy through virtual platforms.
Anti-Inflammatory Properties of Low-Dose Ketamine: Cytokine Modulation
Review of the anti-inflammatory properties of low-dose ketamine, examining cytokine modulation, NF-kappaB signaling, microglial inhibition, and implications for depression and pain.