Research Articles
Latest articles, insights, and updates from the blog.
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BDNF Signaling and Ketamine's Antidepressant Action
A detailed examination of how ketamine activates brain-derived neurotrophic factor signaling, TrkB receptor pathways, and the mTOR cascade to produce rapid antidepressant effects. Covers molecular mechanisms, clinical evidence, and implications for personalized treatment.
Neuroplasticity Mechanisms in Ketamine Therapy
An in-depth exploration of how low-dose ketamine promotes neural rewiring, synaptogenesis, and dendritic spine formation. This article examines the molecular and cellular pathways through which ketamine restores synaptic connectivity in mood and pain disorders.
Ketamine-Opioid System Interactions: Naltrexone Studies and Debate
Analysis of ketamine-opioid system interactions, examining the naltrexone blockade controversy, mu-receptor involvement in antidepressant effects, and implications for clinical practice.
Ketamine and the Default Mode Network: Neuroimaging Evidence
What does ketamine do to the default mode network? A review of fMRI connectivity studies, DMN changes in depression, and what the imaging evidence shows.
Rapid-Onset Antidepressant Mechanisms of Low-Dose Ketamine
An in-depth examination of why and how low-dose ketamine produces antidepressant effects within hours rather than weeks. This article reviews the glutamatergic hypothesis, the role of spontaneous NMDA receptor activity, and emerging theories that distinguish ketamine from conventional antidepressants.
Ketamine, Neuroplasticity, and Brain-Derived Neurotrophic Factor
How does low-dose ketamine drive neuroplasticity? Review of BDNF, mTOR pathway activation, synaptogenesis, and links to rapid antidepressant effects.
Low-Dose Ketamine for Acute Suicidal Ideation: Clinical Evidence
A review of the clinical trial evidence examining low-dose ketamine as an intervention for acute suicidal ideation. This article evaluates randomized controlled trials, naturalistic studies, and emergency department protocols demonstrating ketamine's rapid anti-suicidal effects.
Meta-Analyses of Low-Dose Ketamine for Treatment-Resistant Depression
A comprehensive review of major meta-analyses examining the efficacy and safety of low-dose ketamine in treatment-resistant depression. This overview synthesizes findings across multiple systematic reviews to characterize effect sizes, response rates, and durability of antidepressant outcomes.