Safety Articles
Latest articles, insights, and updates from the blog.
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Ketamine Tolerance and Long-Term Use: What Clinicians Need to Know
Clinical review of tolerance development during long-term ketamine therapy, including mechanisms, detection strategies, and evidence-based management approaches.
Managing Nausea and Vomiting During Ketamine Therapy
Clinical guide to preventing and treating ketamine-induced nausea and vomiting, covering antiemetic protocols, risk factors, and non-pharmacological strategies.
Cognitive Effects of Repeated Low-Dose Ketamine: Neuropsychological Assessment
Does repeated low-dose ketamine affect cognition? Review of memory, attention, and executive function testing across short- and longer-term treatment courses.
Ketamine-Associated Hepatotoxicity: Risk Factors and Liver Function Monitoring
Review of ketamine-associated hepatotoxicity including risk factors, proposed mechanisms, liver function monitoring protocols, and clinical management for repeated therapeutic dosing.
Cardiovascular Effects of Low-Dose Ketamine: Hemodynamic Monitoring Guidelines
Evidence-based hemodynamic monitoring guidelines for low-dose ketamine, covering sympathomimetic cardiovascular effects, blood pressure management, and cardiac risk stratification.
Long-Term Safety Considerations for Ketamine Therapy
What is known about long-term low-dose ketamine safety? Review of cumulative exposure data, organ-specific monitoring, and gaps in multi-year evidence.
Clinically Significant Drug Interactions with Low-Dose Ketamine
Which medications interact with low-dose ketamine? Review of CNS depressants, serotonergic drugs, CYP enzyme effects, and cardiovascular medication overlap.
Contraindications and Screening Protocols for Ketamine Therapy
A thorough guide to absolute and relative contraindications for low-dose ketamine, along with recommended screening protocols encompassing medical history, psychiatric evaluation, laboratory assessment, and informed consent procedures.