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Long-Term Safety Considerations for Ketamine Therapy
What is known about long-term low-dose ketamine safety? Review of cumulative exposure data, organ-specific monitoring, and gaps in multi-year evidence.
Clinically Significant Drug Interactions with Low-Dose Ketamine
Which medications interact with low-dose ketamine? Review of CNS depressants, serotonergic drugs, CYP enzyme effects, and cardiovascular medication overlap.
Weight-Based Dosing Guidelines for Low-Dose Ketamine
Practical guidance on weight-based dosing calculations for low-dose ketamine across clinical indications. Addresses ideal versus actual body weight considerations, dosing ranges by route and indication, and special population adjustments.
Ketamine-Assisted Therapy for PTSD and Trauma
Is ketamine being used for PTSD and cPTSD? A clinical look at low-dose ketamine-assisted psychotherapy, neurobiological rationale, and current trial evidence.
Telemedicine Monitoring Protocols for At-Home Ketamine Therapy
How are patients monitored during at-home low-dose ketamine sessions? Review of remote vitals, observer protocols, video check-ins, and safety frameworks.
Contraindications and Screening Protocols for Ketamine Therapy
A thorough guide to absolute and relative contraindications for low-dose ketamine, along with recommended screening protocols encompassing medical history, psychiatric evaluation, laboratory assessment, and informed consent procedures.
Standard IV Ketamine Infusion Protocols for Treatment-Resistant Depression
How are IV ketamine infusions dosed for treatment-resistant depression? Review of 0.5 mg/kg standard, session structure, monitoring, and evidence base.
Spravato (Esketamine) Nasal Spray Protocol and Administration Guidelines
How is Spravato (esketamine) nasal spray dosed? Review of induction and maintenance schedules, REMS monitoring, and how it compares with racemic ketamine.
Sublingual and Oral Ketamine Protocols for At-Home Depression Treatment
How are sublingual troches and oral low-dose ketamine prescribed at home? Review of dosing strategies, telehealth integration, and patient monitoring.
Geriatric Considerations in Low-Dose Ketamine Therapy
Is ketamine therapy safe for elderly patients? Review of age-related pharmacokinetics, cardiovascular risk, cognitive monitoring, and low-dose adjustments.
Ketamine and the Default Mode Network: Neuroimaging Evidence
What does ketamine do to the default mode network? A review of fMRI connectivity studies, DMN changes in depression, and what the imaging evidence shows.
Low-Dose Ketamine for Chronic Pain Syndromes
A clinical review of subanesthetic ketamine infusion therapy for chronic pain conditions including complex regional pain syndrome, fibromyalgia, and neuropathic pain, covering mechanisms, protocols, and evidence.