Blog
Latest articles, insights, and updates from the blog.
Ketamine-Assisted Therapy for PTSD and Trauma
A clinical examination of low-dose ketamine as an adjunct to psychotherapy for post-traumatic stress disorder, exploring its neurobiological rationale, emerging trial data, and integration with trauma-focused therapeutic modalities.
Telemedicine Monitoring Protocols for At-Home Ketamine Therapy
Evidence-based guidance on remote monitoring protocols for at-home ketamine administration, covering vital sign monitoring, telehealth check-ins, safety frameworks, and technology requirements.
Sublingual and Oral Ketamine Protocols for At-Home Depression Treatment
An evidence-informed guide to sublingual ketamine troches and oral ketamine protocols used in at-home treatment models, including prescribing considerations, dosing strategies, telehealth integration, patient safety frameworks, and clinical monitoring requirements.
Spravato (Esketamine) Nasal Spray Protocol and Administration Guidelines
A detailed clinical guide to the FDA-approved intranasal esketamine (Spravato) protocol, covering REMS program requirements, dosing schedules, administration procedures, and post-dose monitoring for treatment-resistant depression and major depressive disorder with suicidal ideation.
Standard IV Ketamine Infusion Protocols for Treatment-Resistant Depression
A comprehensive overview of intravenous ketamine infusion protocols used in clinical settings for treatment-resistant depression, including dosing parameters, session structure, monitoring requirements, and evidence-based best practices.
Contraindications and Screening Protocols for Ketamine Therapy
A thorough guide to absolute and relative contraindications for low-dose ketamine, along with recommended screening protocols encompassing medical history, psychiatric evaluation, laboratory assessment, and informed consent procedures.
Geriatric Considerations in Low-Dose Ketamine Therapy
Clinical guidance on low-dose ketamine use in elderly patients, addressing age-related pharmacokinetic changes, cardiovascular risk stratification, cognitive monitoring, and dose modifications.
Low-Dose Ketamine for Chronic Pain Syndromes
A clinical review of subanesthetic ketamine infusion therapy for chronic pain conditions including complex regional pain syndrome, fibromyalgia, and neuropathic pain, covering mechanisms, protocols, and evidence.
Pharmacokinetics of Ketamine: Absorption, Distribution, Metabolism, and Elimination
A comprehensive overview of ketamine pharmacokinetics across all clinically relevant routes of administration. Covers bioavailability, volume of distribution, hepatic metabolism via CYP enzymes, half-life considerations, and the role of active metabolites.
Ketamine and the Default Mode Network: Neuroimaging Evidence
Review of neuroimaging evidence on ketamine's effects on the default mode network (DMN), examining fMRI connectivity changes, depression biomarkers, and implications for treatment.
Renal and Hepatic Dose Adjustments for Low-Dose Ketamine
Pharmacokinetic rationale and clinical guidelines for ketamine dose adjustments in patients with renal impairment or hepatic dysfunction, including monitoring strategies and contraindication thresholds.
Defining Sub-Anesthetic Ketamine: Dose Ranges and Therapeutic Windows
Comprehensive guide to sub-anesthetic ketamine dose ranges and therapeutic windows, covering pharmacological thresholds, receptor occupancy, and clinical dose-response relationships.
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