Blog
Latest articles, insights, and updates from the blog.
Ketamine and the Gut-Brain Axis: How the Microbiome Influences Treatment Response
An in-depth look at the emerging research connecting ketamine therapy to the gut-brain axis, including how gut microbiome composition may predict and modulate ketamine's antidepressant and analgesic effects.
How Fast Does Ketamine Work for Depression?
Low-dose ketamine can produce antidepressant effects within hours, with most patients noticing improvement in 1 to 4 hours after an IV infusion.
Glutamate System Modulation by Low-Dose Ketamine
A comprehensive analysis of how low-dose ketamine modulates the glutamate system, including NMDA receptor antagonism, AMPA receptor potentiation, and the glutamate surge hypothesis. Reviews the excitatory-inhibitory balance framework and its therapeutic implications.
Ketamine and the Default Mode Network: Neuroimaging Evidence
Review of neuroimaging evidence on ketamine's effects on the default mode network (DMN), examining fMRI connectivity changes, depression biomarkers, and implications for treatment.
BDNF Signaling and Ketamine's Antidepressant Action
A detailed examination of how ketamine activates brain-derived neurotrophic factor signaling, TrkB receptor pathways, and the mTOR cascade to produce rapid antidepressant effects. Covers molecular mechanisms, clinical evidence, and implications for personalized treatment.
Biomarkers for Predicting Ketamine Treatment Response
A review of emerging biological markers that may predict which patients will respond to ketamine therapy, including inflammatory markers, neuroimaging signatures, genetic polymorphisms, and electrophysiological features.
Anti-Inflammatory Properties of Low-Dose Ketamine: Cytokine Modulation
Review of the anti-inflammatory properties of low-dose ketamine, examining cytokine modulation, NF-kappaB signaling, microglial inhibition, and implications for depression and pain.
What Happens During a Ketamine Infusion?
A ketamine infusion involves a 40-minute IV drip in a clinical setting, with vital sign monitoring and a 1 to 2 hour observation period afterward.
Treatment-Resistant Depression Algorithms: Where Ketamine Fits
Analysis of where ketamine fits within treatment-resistant depression algorithms, reviewing staging models, sequencing strategies, and evidence-based positioning in the TRD pathway.
Telehealth Ketamine Therapy: Protocols and Best Practices
A comprehensive guide to telehealth-delivered ketamine therapy, covering regulatory frameworks, clinical protocols for remote prescribing and monitoring, patient selection, and quality standards for virtual ketamine treatment programs.
Discontinuing Ketamine Therapy: Tapering, Timing, and Monitoring
Clinical guidance on when and how to discontinue ketamine therapy, covering tapering protocols, relapse monitoring strategies, transition planning, and evidence-based criteria for treatment cessation.
Sublingual and Oral Ketamine Protocols for At-Home Depression Treatment
An evidence-informed guide to sublingual ketamine troches and oral ketamine protocols used in at-home treatment models, including prescribing considerations, dosing strategies, telehealth integration, patient safety frameworks, and clinical monitoring requirements.
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