Blog
Latest articles, insights, and updates from the blog.
Renal and Hepatic Dose Adjustments for Low-Dose Ketamine
Pharmacokinetic rationale and clinical guidelines for ketamine dose adjustments in patients with renal impairment or hepatic dysfunction, including monitoring strategies and contraindication thresholds.
Pharmacokinetics of Ketamine: Absorption, Distribution, Metabolism, and Elimination
A comprehensive overview of ketamine pharmacokinetics across all clinically relevant routes of administration. Covers bioavailability, volume of distribution, hepatic metabolism via CYP enzymes, half-life considerations, and the role of active metabolites.
Pediatric Low-Dose Ketamine: Dosing Considerations and Safety
Review of pediatric low-dose ketamine dosing considerations, covering developmental pharmacokinetics, age-specific safety data, and clinical applications in children and adolescents.
Ketamine Tolerance: Understanding Dose Adjustments Over Time
A clinical review of tolerance development during repeated ketamine treatment, covering pharmacological mechanisms of tolerance, clinical indicators, evidence-based dose adjustment strategies, and the distinction between therapeutic tolerance and treatment failure.
Optimizing Oral Ketamine Bioavailability: Pharmacokinetic Strategies
Pharmacokinetic strategies for optimizing oral ketamine bioavailability, including sublingual administration, formulation approaches, metabolic inhibition, and clinical considerations.
What Is Ketamine's Half-Life?
Ketamine has a plasma half-life of approximately 2 to 3 hours, though its antidepressant effects persist far longer due to downstream neuroplastic changes.
How Many Ketamine Treatments Are Needed?
A typical initial course of ketamine therapy consists of 6 IV infusions over 2 to 3 weeks, followed by maintenance treatments as needed.
Esketamine vs Racemic Ketamine Dosing: Comparative Pharmacology
Comparative pharmacology of esketamine versus racemic ketamine dosing, examining enantiomer-specific receptor binding, clinical potency differences, and dosing equivalencies.
Low-Dose Ketamine for Treatment-Resistant Depression
An evidence-based overview of low-dose ketamine as a rapidly acting antidepressant for patients with treatment-resistant depression, including mechanisms of action, clinical protocols, and outcome data.
Dose-Response Relationships in Low-Dose Ketamine Therapy
An in-depth examination of ketamine dose-response curves across indications including depression, chronic pain, and procedural analgesia. Covers threshold doses, ceiling effects, and how response varies with clinical context.
Ketamine-Assisted Therapy for Substance Use Disorders: Clinical Trials Review
Review of ketamine-assisted therapy for substance use disorders including alcohol, cocaine, and opioid dependence — examining clinical trials, neuroplasticity mechanisms, and outcomes.
Low-Dose Ketamine for Social Anxiety Disorder: Preliminary Evidence
Examining preliminary evidence for low-dose ketamine in social anxiety disorder, including glutamatergic mechanisms, neuroimaging findings, and early-phase clinical data.
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