Blog
Latest articles, insights, and updates from the blog.
Informed Consent for Ketamine Treatment: Essential Elements
Guide to informed consent for ketamine treatment, covering essential disclosure elements, off-label considerations, risk communication, and documentation best practices.
Ketamine for OCD: Glutamatergic Modulation of Obsessive-Compulsive Circuits
Review of ketamine in OCD treatment, examining glutamatergic modulation of cortico-striato-thalamo-cortical circuits, clinical trial evidence, and rapid anti-obsessional effects.
Neuroplasticity Mechanisms in Ketamine Therapy
An in-depth exploration of how low-dose ketamine promotes neural rewiring, synaptogenesis, and dendritic spine formation. This article examines the molecular and cellular pathways through which ketamine restores synaptic connectivity in mood and pain disorders.
Ketamine-Opioid System Interactions: Naltrexone Studies and Debate
Analysis of ketamine-opioid system interactions, examining the naltrexone blockade controversy, mu-receptor involvement in antidepressant effects, and implications for clinical practice.
Optimizing Oral Ketamine Bioavailability: Pharmacokinetic Strategies
Pharmacokinetic strategies for optimizing oral ketamine bioavailability, including sublingual administration, formulation approaches, metabolic inhibition, and clinical considerations.
Ketamine Maintenance Infusion Protocols: Frequency and Duration Optimization
Evidence-based review of ketamine maintenance infusion protocols, covering optimal frequency, duration, tapering strategies, and long-term outcomes for sustained treatment response.
Cardiovascular Effects of Low-Dose Ketamine: Hemodynamic Monitoring Guidelines
Evidence-based hemodynamic monitoring guidelines for low-dose ketamine, covering sympathomimetic cardiovascular effects, blood pressure management, and cardiac risk stratification.
Low-Dose Ketamine for Bipolar Depression: Efficacy and Safety Data
Comprehensive review of low-dose ketamine for bipolar depression, examining clinical trial efficacy, safety profiles, and rapid-acting antidepressant mechanisms in bipolar disorder.
Low-Dose Ketamine for Anxiety Disorders
A clinical overview of subanesthetic ketamine's therapeutic potential in generalized anxiety disorder, social anxiety disorder, and obsessive-compulsive disorder, including mechanistic pathways, current evidence, and considerations for clinical practice.
Long-Term Safety Considerations for Ketamine Therapy
An evidence-based review of safety concerns associated with repeated or prolonged low-dose ketamine use, including urological toxicity, neurocognitive effects, hepatic complications, and the potential for psychological and physiological dependence.
Clinically Significant Drug Interactions with Low-Dose Ketamine
A comprehensive review of clinically significant drug interactions with therapeutic ketamine, covering CNS depressants, serotonergic agents, CYP enzyme inhibitors, and cardiovascular medications.
Weight-Based Dosing Guidelines for Low-Dose Ketamine
Practical guidance on weight-based dosing calculations for low-dose ketamine across clinical indications. Addresses ideal versus actual body weight considerations, dosing ranges by route and indication, and special population adjustments.
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