Blog
Latest articles, insights, and updates from the blog.
Ketamine Tolerance and Long-Term Use: What Clinicians Need to Know
Clinical review of tolerance development during long-term ketamine therapy, including mechanisms, detection strategies, and evidence-based management approaches.
Managing Nausea and Vomiting During Ketamine Therapy
Clinical guide to preventing and treating ketamine-induced nausea and vomiting, covering antiemetic protocols, risk factors, and non-pharmacological strategies.
Cognitive Effects of Repeated Low-Dose Ketamine: Neuropsychological Assessment
Review of cognitive effects of repeated low-dose ketamine treatment, covering acute and chronic impacts on memory, executive function, and neuropsychological assessment strategies.
Does Ketamine Affect Sleep? Low-Dose Ketamine and Sleep Architecture
Evidence-based review of how low-dose ketamine affects sleep quality, architecture, and insomnia in patients with depression and chronic pain.
Measuring Ketamine Treatment Outcomes: Validated Assessment Tools
Review of validated assessment tools for measuring ketamine treatment outcomes, covering depression rating scales, suicidality measures, functional assessments, and biomarkers.
Esketamine vs Racemic Ketamine Dosing: Comparative Pharmacology
Comparative pharmacology of esketamine versus racemic ketamine dosing, examining enantiomer-specific receptor binding, clinical potency differences, and dosing equivalencies.
Anti-Inflammatory Properties of Low-Dose Ketamine: Cytokine Modulation
Review of the anti-inflammatory properties of low-dose ketamine, examining cytokine modulation, NF-kappaB signaling, microglial inhibition, and implications for depression and pain.
BDNF Signaling and Ketamine's Antidepressant Action
A detailed examination of how ketamine activates brain-derived neurotrophic factor signaling, TrkB receptor pathways, and the mTOR cascade to produce rapid antidepressant effects. Covers molecular mechanisms, clinical evidence, and implications for personalized treatment.
Ketamine-Assisted Therapy for Substance Use Disorders: Clinical Trials Review
Review of ketamine-assisted therapy for substance use disorders including alcohol, cocaine, and opioid dependence — examining clinical trials, neuroplasticity mechanisms, and outcomes.
Ketamine Combination Therapy: Augmentation Strategies with Existing Treatments
Review of ketamine combination therapy and augmentation strategies, examining interactions with antidepressants, lithium, benzodiazepines, and psychotherapy for optimized outcomes.
Ketamine-Associated Hepatotoxicity: Risk Factors and Liver Function Monitoring
Review of ketamine-associated hepatotoxicity including risk factors, proposed mechanisms, liver function monitoring protocols, and clinical management for repeated therapeutic dosing.
Low-Dose Ketamine for Social Anxiety Disorder: Preliminary Evidence
Examining preliminary evidence for low-dose ketamine in social anxiety disorder, including glutamatergic mechanisms, neuroimaging findings, and early-phase clinical data.
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